BIN1 Proteins, cDNA Clones Research Reagents

All BIN1 reagents are produced in house and quality controlled, including 2 BIN1 Gene, 1 BIN1 Protein, 1 BIN1 qPCR. All BIN1 reagents are ready to use.

BIN1 Protein (1)

    BIN1 cDNA Clone (2)

    NM_139350.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    BIN1 qPCR Primer (1)

    BIN1 の背景知識

    Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicated in rare and common diseases affecting different tissues and physiological functions. BIN1 downregulation is linked to cancer progression and also correlates with ventricular cardiomyopathy and arrhythmia preceding heart failure. Increased BIN1 expression is linked to increased susceptibility for late-onset Alzheimer's disease. In addition, altered splicing may account for the muscle component of myotonic dystrophies, while recessive germinal mutations cause centronuclear myopathy. Bridging integrator 1 (BIN1) as a late-onset Alzheimer's disease (AD) susceptibility gene. There are at least 15 different known isoforms of BIN1, with many being expressed in the brain including the longest isoform (iso1), which is brain-specific and localizes to axon initial segments and nodes of Ranvier. The bridging integrator 1 (BIN1) tumor suppressor encodes multiple alternatively spliced isoforms implicated in DNA repair, cell-cycle control, apoptosis and membrane dynamics.

    BIN1 の参考文献

    • Eisenman RN. (2001) Deconstructing Myc. Genes & Dev. 15: 2023-30
    • Bouchard C, et al. (1998) Control of cell proliferation by Myc. Trends in Cell Biology. 8(5): 202-6.
    • Sakamurol D, et al. (1996) BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nature Genetics. 14: 69-77.

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