BID Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All BID reagents are produced in house and quality controlled, including 11 BID Antibody, 2 BID ELISA, 30 BID Gene, 5 BID IP Kit, 2 BID Protein, 2 BID qPCR. All BID reagents are ready to use.

BID Protein (2)

    BID Antibody (11)

      BID ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      BID cDNA Clone (30)

      NM_001196.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_007544.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      BID の背景知識

      The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals. Recent studies further indicate that Bid may be more than just a killer molecule, it could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint. BID is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent. BID is activated by Caspase 8 in response to Fas/TNF-R1 death receptor activation. Activated BID is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. BID action has been proposed to involve the mitochondrial re-location of its truncated form, tBid, to facilitate the release of apoptogenic proteins like cytochrome c.

      BID の参考文献

      • Gross A. (2006) BID as a double agent in cell life and death. Cell Cycle. 5(6): 582-4.
      • Yin XM. (2007) Bid, a BH3-only multi-functional molecule, is at the cross road of life and death. Gene. 369: 7-19.
      • Esposti MD. (2002) The roles of Bid. Apoptosis. 7(5): 433-40.
      • Yin XM. (2000) Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways. Cell Res. 10(3): 161-7.
      • Yin XM. (2000) Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes. J Mol Med. 78(4): 203-11.

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.