BAG3 Antibodies, cDNA Clones Research Reagents

All BAG3 reagents are produced in house and quality controlled, including 2 BAG3 Antibody, 18 BAG3 Gene. All BAG3 reagents are ready to use.

BAG3 Antibody (2)

    BAG3 cDNA Clone (18)

    NM_004281.3

    In expression vector

    NM_013863.5

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001011936.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    BAG3 の背景知識

    Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid protein that is found predominantly in the heart, skeletal muscle, and many cancers. Deletions and truncations in BAG3 that result in haplo-insufficiency have been associated with the development of dilated cardiomyopathy. BAG3 is a stress-induced molecular co-chaperone that functions to regulate cellular protein homeostasis and cell survival via Chaperone-Assisted Selective Autophagy (CASA). CASA and specifically BAG3 may represent a novel host defense mechanism, whereby BAG3 may dampen egress of several hemorrhagic fever viruses by interacting and interfering with the budding function of viral PPxY-containing matrix proteins. BCL2-associated athanogene (BAG)-3 is viewed as a platform that would physically and functionally link distinct classes of molecular chaperones of the heat shock protein (HSP) family for the stabilization and clearance of damaged proteins. The HSPB8-BAG3 connection in mounting of an efficient stress response, which may be involved in BAG3-related human diseases. Both Bcl-2-associated athanogene 3 (BAG3) and tumor necrosis factor-related apopt-osis inducing ligand (TRAIL) involved in apoptosis.

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