Azurocidin/CAP37 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All Azurocidin/CAP37 reagents are produced in house and quality controlled, including 5 Azurocidin/CAP37 Antibody, 2 Azurocidin/CAP37 ELISA, 13 Azurocidin/CAP37 Gene, 1 Azurocidin/CAP37 Lysate, 1 Azurocidin/CAP37 Protein, 1 Azurocidin/CAP37 qPCR. All Azurocidin/CAP37 reagents are ready to use.

Azurocidin/CAP37 Protein (1)

    Azurocidin/CAP37 Antibody (5)

      Azurocidin/CAP37 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      Azurocidin/CAP37 cDNA Clone (13)

      NM_001700.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      Azurocidin/CAP37 qPCR Primer (1)

      Azurocidin/CAP37 Lysate (1)

        Azurocidin/CAP37 の背景知識

        Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, neutrophil elastase (NE), and proteinase 3 (PR3), however, Azurocidin is not a serine proteinase since the active site serine and histidine residues are replaced. Neutrophils arriving first at sites of inflammation release Azurocidin, which acts in a paracrine fashion on endothelial cells causing the development of intercellular gaps and allowing leukocyte extravasation. It thus be regarded as a reasonable therapeutic target for a variety of inflammatory disease conditions.

        Azurocidin/CAP37 の参考文献

        • Lindmark A, et al. (1999) Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin. J Leukoc Biol. 66(4): 634-43.
        • Heinzelmann M, et al. (2001) Heparin binding protein (CAP37) differentially modulates endotoxin-induced cytokine production. Int J Surg Investig. 2(6): 457-66.
        • Soehnlein O, et al. (2005) Neutrophil-derived heparin-binding protein (HBP/CAP37) deposited on endothelium enhances monocyte arrest under flow conditions. J Immunol. 174(10): 6399-405.

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