ATP citrate lyase/ACLY Proteins, Antibodies, cDNA Clones Research Reagents

All ATP citrate lyase/ACLY reagents are produced in house and quality controlled, including 1 ATP citrate lyase/ACLY Antibody, 1 ATP citrate lyase/ACLY Gene, 1 ATP citrate lyase/ACLY IP Kit, 1 ATP citrate lyase/ACLY Lysate, 1 ATP citrate lyase/ACLY Protein. All ATP citrate lyase/ACLY reagents are ready to use.

ATP citrate lyase/ACLY Protein (1)

    ATP citrate lyase/ACLY Antibody (1)

      ATP citrate lyase/ACLY cDNA Clone (1)

      NM_001096.2

      In expression vector

      ATP citrate lyase/ACLY Lysate (1)

        ATP citrate lyase/ACLY の背景知識

        ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP citrate lyase is responsible for catalyzing the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, along with the hydrolysis of ATP. A definitive role for ATP citrate lyase in tumorigenesis has emerged from ATP citrate lyase RNAi and chemical inhibitor studies, showing that ATP citrate lyase inhibition limits tumor cell proliferation and survival and induces differentiation in vitro. In vivo, it reduces tumor growth leading to a cytostatic effect and induces differentiation.

        ATP citrate lyase/ACLY の参考文献

        • Kim W, et al. (2006) Both subunits of ATP-citrate lyase from Chlorobium tepidum contribute to catalytic activity. J Bacteriol. 188 (18) : 6544-52.
        • Ki SW, et al. (2000) Radicicol binds and inhibits mammalian ATP citrate lyase. J Biol Chem. 275 (50) : 39231-6.
        • Schneider K, et al. (2000) Biosynthesis of the prosthetic group of citrate lyase. Biochemistry. 39 (31) : 9438-50.

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