ATOX1 Proteins, Antibodies, cDNA Clones Research Reagents

All ATOX1 reagents are produced in house and quality controlled, including 2 ATOX1 Antibody, 30 ATOX1 Gene, 1 ATOX1 Protein, 1 ATOX1 qPCR. All ATOX1 reagents are ready to use.

ATOX1 Protein (1)

    ATOX1 Antibody (2)

      ATOX1 cDNA Clone (30)

      BC112248

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_009720.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      ATOX1 qPCR Primer (1)

      ATOX1 の背景知識

      ATOX1 is a cytoplasmic copper chaperone that interacts with the copper-binding domain of the membrane copper transporters ATP7A and ATP7B. ATOX1 has also been suggested to have a potential anti-oxidant activity. As the trace element copper is essential, but extremely toxic in high concentrations, intracellular copper concentrations are tightly controlled. Once in the cell, copper is distributed by metallochaperones, including the small cytoplasmic protein ATOX1. ATOX1 plays an important role in the transfer of copper to the copper export P-type ATPases ATP7A and ATP7B to facilitate copper excretion. There is a novel function for Atox1 as a transcription factor (TF) regulating Ccnd1 was proposed. Antioxidant 1 (ATOX1) functions as an antioxidant against hydrogen peroxide and superoxide, and therefore may play a significant role in many human diseases, including diabetes mellitus (DM). The transduced Tat-ATOX1 protein protects pancreatic beta-cells by inhibiting STZ-induced cellular toxicity in vitro and in vivo. Thus Tat-ATOX1 protein has potential applications as a therapeutic agent for oxidative stress-induced diseases including DM.

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.