Aromatase/CYP19A1 Antibodies, cDNA Clones Research Reagents

All Aromatase/CYP19A1 reagents are produced in house and quality controlled, including 3 Aromatase/CYP19A1 Antibody, 13 Aromatase/CYP19A1 Gene, 1 Aromatase/CYP19A1 qPCR. All Aromatase/CYP19A1 reagents are ready to use.

Aromatase/CYP19A1 Antibody (3)

    Aromatase/CYP19A1 cDNA Clone (13)

    BC035959

    クローニングベクター cDNA 製品

    In lentiviral vector

    Aromatase/CYP19A1 qPCR Primer (1)

    Aromatase/CYP19A1 の背景知識

    The cytochrome P450 family 19 subfamily A member 1 (CYP19A1) gene, encodes aromatase, a key enzyme in estradiol (E2) synthesis, and is down-regulated during porcine follicular atresia. CYP19A1 gene stimulates E2 release and inhibits cell apoptosis in porcine granulosa cells (GCs). The single nucleotide polymorphisms in CYP19A1 gene may alter aromatase activity and circulating steroid hormone levels in females. High CYP19A1 expression was highly significantly associated with a poor overall, disease-free, and metastasis-free survival in estrogen receptor-positive but not negative breast cancer patients. Estrogen production by the human villous trophoblast is dependent on the biosynthetic enzyme aromatase (CYP19; CYP19A1) and is crucial for successful placental development and pregnancy outcome.

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