ARIH2 Antibodies, cDNA Clones Research Reagents

All ARIH2 reagents are produced in house and quality controlled, including 1 ARIH2 Antibody, 32 ARIH2 Gene, 1 ARIH2 qPCR. All ARIH2 reagents are ready to use.

ARIH2 Antibody (1)

    ARIH2 cDNA Clone (32)

    BC000422

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001012275.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    AB172067.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    ARIH2 qPCR Primer (1)

    ARIH2 の背景知識

    ARIH2 encodes the Triad1 protein, an anti-proliferative E3 ubiquitin ligase. In the current study, we investigate the role of Triad1 in leukemogenesis induced by an MLL1 fusion protein (Mll-Ell). we investigate the role of Triad1 in leukemogenesis induced by an MLL1 fusion protein (Mll-Ell), relevant Triad1 substrates may indicate novel therapeutic targets in this disease. E3 ligase, Ariadne homolog 2 (ARIH2), as a posttranslational negative regulator of NLRP3 inflammasome activity in macrophages. ARIH2 interacted with NLRP3 via its NACHT domain (aa 220-575) in the NLRP3 inflammasome complex. ARIH2 overexpression promoted NLRP3 ubiquitination and inhibited NLRP3 inflammasome activation. Reveal a novel mechanism of ubiquitination-dependent negative regulation of the NLRP3 inflammasome by ARIH2 and highlight ARIH2 as a potential therapeutic target for inflammatory diseases.

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