APOBEC2 Antibodies, cDNA Clones Research Reagents

All APOBEC2 reagents are produced in house and quality controlled, including 1 APOBEC2 Antibody, 30 APOBEC2 Gene, 2 APOBEC2 qPCR. All APOBEC2 reagents are ready to use.

APOBEC2 Antibody (1)

    APOBEC2 cDNA Clone (30)

    NM_006789.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001106883.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    APOBEC2 の背景知識

    Apolipoprotein B mRNA-editing enzyme catalytic subunit 2 (APOBEC2) is a member of the nucleic-acid-editing enzymes. APOBEC2 expression is regulated by pro-inflammatory cytokines via NF-kappaB activation and suggest a possible role of APOBEC2 in the pathophysiology of hepatic inflammation. APOBEC2-deficient mice harbor a markedly increased ratio of slow to fast fibers in soleus muscle and exhibit an approximately 15-20% reduction in body mass from birth onwards, with elderly mutant animals revealing clear histological evidence of a mild myopathy. Apolipoprotein B mRNA editing enzyme catalytic polypeptide 2 (APOBEC2) was originally identified as a member of the cytidine deaminase family with putative nucleotide editing activity. Together with the fact that the proinflammatory cytokine tumor necrosis factor-alpha induces ectopic expression of APOBEC2 in hepatocytes, our findings indicate that aberrant APOBEC2 expression causes nucleotide alterations in the transcripts of the specific target gene and could be involved in the development of human hepatocellular carcinoma through hepatic inflammation. Apolipoprotein B mRNA-editing enzyme catalytic subunit 2 (APOBEC2) plays an important role in regulating and maintaining muscle development in mammals. APOBEC2 was expressed as the greatest in skeletal muscle and cardiac muscle where it localized to the nucleus. Thus, APOBEC2 may play an important role in muscle development in chickens.

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