APEH/AARE Antibodies, cDNA Clones Research Reagents

All APEH/AARE reagents are produced in house and quality controlled, including 1 APEH/AARE Antibody, 31 APEH/AARE Gene, 2 APEH/AARE qPCR. All APEH/AARE reagents are ready to use.

APEH/AARE Antibody (1)

    APEH/AARE cDNA Clone (31)

    NM_001640.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_146226.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_012500.1

    クローニングベクター cDNA 製品

    APEH/AARE の背景知識

    Acylpeptide hydrolase (APEH) is a ubiquitous cytosolic protease that plays an important role in the detoxification of oxidised proteins. SsCEI 4 triggered a proliferative arrest specifically in osteosarcoma U2OS cells via downregulation of the APEH-proteasome system, with the accumulation of the typical hallmarks of proteasome: NF-kappaB, p21(Waf1), and polyubiquitinylated proteins. We found that the SsCEI 4 anti-proliferative effect involved a senescence-like growth arrest without noticeable cytotoxicity. These findings represent an important step toward understanding the mechanism(s) underlying the APEH-mediated downregulation of proteasome in order to design new molecules able to efficiently regulate the proteasome system for alternative therapeutic strategies.

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