Allergin 1 Proteins, cDNA Clones Research Reagents

MILR1 (Mast Cell Immunoglobulin Like Receptor 1, also known as MCA32; MCA-32; C17orf60; Allergin-1), located on 17q23.3, is a Protein Coding gene. The gene produces a 38735 Da protein composed of 343 amino acids. Cell surface immunoreceptor MILR1 has been shown to suppress immunoglobulin E (IgE)-mediated, mast cell-dependent responses in both mice and humans. MILR1 is broadly expressed in the appendix, lymph node, and other tissues. Diseases such as Mitochondrial Dna Depletion Syndrome 16 and Autosomal Dominant Progressive External Ophthalmoplegia are associated with MILR1.

Allergin 1 Protein (3)

    Allergin 1 cDNA Clone (16)

    NM_001085423.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001033435.3

    In expression vector

    In lentiviral vector

    XM_005584708.2

    In expression vector

    Allergin 1 Lysate (3)

      Allergin 1 の背景知識

      MILR1 (Mast Cell Immunoglobulin Like Receptor 1, also known as MCA32) is a Protein Coding gene. It is broadly expressed in the appendix, lymph node, and other tissues. Cell surface immunoreceptor MILR1 has been shown to suppress immunoglobulin E (IgE)-mediated, mast cell-dependent responses in both mice and humans. The C allele of rs6504230 was associated with increased expression of MILR1, which was following the results of expression quantitative trait loci analysis using human leukocytes. The rs6504230 polymorphism affects MILR1 expression levels in humans, leading to a susceptibility to producing specific IgE antibodies against common allergens. Diseases associated with MILR1 include Mitochondrial Dna Depletion Syndrome 16 and Autosomal Dominant Progressive External Ophthalmoplegia.

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