Aldolase B Proteins, Antibodies, cDNA Clones Research Reagents

All Aldolase B reagents are produced in house and quality controlled, including 2 Aldolase B Antibody, 45 Aldolase B Gene, 1 Aldolase B Protein, 2 Aldolase B qPCR. All Aldolase B reagents are ready to use.

Aldolase B Protein (1)

    Aldolase B Antibody (2)

      Aldolase B cDNA Clone (45)

      NM_000035.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_144903.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_012496.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      Aldolase B の背景知識

      The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. Via GATA6, metastatic cells in the liver upregulate the enzyme aldolase B (ALDOB), which enhances fructose metabolism and provides fuel for major pathways of central carbon metabolism during tumor cell proliferation. Targeting ALDOB or reducing dietary fructose significantly reduces liver metastatic growth but has little effect on the primary tumor. Hereditary fructose intolerance (HFI) is an autosomal recessive disorder caused by aldolase B (ALDOB) deficiency resulting in an inability to metabolize fructose. The toxic accumulation of intermediate fructose-1-phosphate causes multiple metabolic disturbances, including postprandial hypoglycemia, lactic acidosis, electrolyte disturbance, and liver/kidney dysfunction.

      Aldolase B の参考文献

      • Cox TM. (1994) Aldolase B and fructose intolerance. FASEB J. 8(1): 62-71.
      • Malay AD, et al. (2005) Structure of the thermolabile mutant aldolase B, A149P: molecular basis of hereditary fructose intolerance. J Mol Biol. 347(1): 135-44.
      • Susan PP, et al. (2001) Starvation-induced lysosomal degradation of aldolase B requires glutamine 111 in a signal sequence for chaperone-mediated transport. J Cell Physiol. 187(1): 48-58.

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