ALDH7A1 Proteins, Antibodies, cDNA Clones Research Reagents

All ALDH7A1 reagents are produced in house and quality controlled, including 8 ALDH7A1 Antibody, 45 ALDH7A1 Gene, 2 ALDH7A1 IP Kit, 1 ALDH7A1 Protein, 2 ALDH7A1 qPCR. All ALDH7A1 reagents are ready to use.

ALDH7A1 Protein (1)

    ALDH7A1 Antibody (8)

      ALDH7A1 cDNA Clone (45)

      BC012407.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001271105.1

      クローニングベクター cDNA 製品

      XM_002710171.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      ALDH7A1 の背景知識

      ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Mammalian ALDH7A1 is homologous to plant ALDH7B1 which protects against various forms of stress such as increased salinity, dehydration and treatment with oxidants or pesticides. In mammals, ALDH7A1 is known to play a primary role during lysine catabolism through the NAD+-dependent oxidative conversion of aminoadipate semialdehyde (AASA) to its corresponding carboxylic acid, α-aminoadipic acid. Deleterious mutations in human ALDH7A1 are responsible for pyridoxine-dependent and folinic acid-responsive seizures. ALDH7A1 is a novel aldehyde dehydrogenase expressed in multiple subcellular compartments that protects against hyperosmotic stress by generating osmolytes and metabolizing toxic aldehydes.

      ALDH7A1 の参考文献

      • Brocker C, et al. (2011) Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity. Chem Biol Interact. 191(1-3): 269-77.
      • Brocker C, et al. (2010) Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress. J Biol Chem. 285(24): 18452-63.

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