ALDH4A1 Proteins, Antibodies, cDNA Clones Research Reagents

All ALDH4A1 reagents are produced in house and quality controlled, including 4 ALDH4A1 Antibody, 19 ALDH4A1 Gene, 2 ALDH4A1 IP Kit, 2 ALDH4A1 Lysate, 2 ALDH4A1 Protein, 1 ALDH4A1 qPCR. All ALDH4A1 reagents are ready to use.

ALDH4A1 Protein (2)

    ALDH4A1 Antibody (4)

      ALDH4A1 cDNA Clone (19)


      クローニングベクター cDNA 製品

      In lentiviral vector


      クローニングベクター cDNA 製品

      In lentiviral vector


      クローニングベクター cDNA 製品

      ALDH4A1 qPCR Primer (1)

      ALDH4A1 Lysate (2)

        ALDH4A1 の背景知識

        ALDH4A1 is a member of the aldehyde dehydrogenase family. Aldehyde dehydrogenase enzymes function in the metabolism of many molecules including certain fats (cholesterol and other fatty acids) and protein building blocks (amino acids). Additional aldehyde dehydrogenase enzymes detoxify external substances, such as alcohol and pollutants, and internal substances, such as toxins that are formed within cells. ALDH4A1 is expressed abundantly in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas. It is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Defects in ALDH4A1 are the cause of hyperprolinemia type 2 (HP-2). HP-2 is characterized by the accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. The disorder may be causally related to neurologic manifestations, including seizures and mental retardation.

        ALDH4A1 の参考文献

        • Goodman SI, et al. (1974) Defective hydroxyproline metabolism in type II hyperprolinemia. Biochemical medicine. 10 (4): 329-36.
        • Maruyama K, et al. (1994) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 138 (1-2): 171-4.
        • Vasiliou V, et al. (2005) Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family. Hum Genomics. 2 (2): 138-43.

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