ALDH1A3 Proteins, cDNA Clones Research Reagents

All ALDH1A3 reagents are produced in house and quality controlled, including 15 ALDH1A3 Gene, 1 ALDH1A3 Protein, 1 ALDH1A3 qPCR. All ALDH1A3 reagents are ready to use.

ALDH1A3 Protein (1)

    ALDH1A3 cDNA Clone (15)

    NM_000693.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    ALDH1A3 qPCR Primer (1)

    ALDH1A3 の背景知識

    Aldehyde dehydrogenase 1 family, member A3 (ALDH1A3), also known as Retinaldehyde dehydrogenase 3 (RALDH3), which belongs to the aldehyde dehydrogenase family. ALDH1A3 is a novel Cancer stem cell (CSC) marker with potential clinical prognostic applicability, and demonstrates a clear correlation between CSC prevalence and the development of metastatic breast cancer. The retinoic acid (RA) biosynthesis enzyme aldehyde dehydrogenase 1A3 (ALDH1A3) is a putative androgen-responsive gene in human prostate cancer epithelial (LNCaP) cells. The RA biosynthesis enzyme ALDH1A3 is androgen responsive and (ii) DHT up-regulation of ALDH1A3 can increase the oxidation of retinal to RA and indirectly affect RA bioactivity and metabolism.

    ALDH1A3 の参考文献

    • Marcato P, et al. (2011) Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis. Stem Cells. 29(1)32-45.
    • Trasino SE, et al. (2007) Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP. Exp Biol Med (Maywood). 232(6): 762-71.

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