AKR1A1 Proteins, Antibodies, cDNA Clones Research Reagents

All AKR1A1 reagents are produced in house and quality controlled, including 1 AKR1A1 Antibody, 45 AKR1A1 Gene, 1 AKR1A1 Protein, 2 AKR1A1 qPCR. All AKR1A1 reagents are ready to use.

AKR1A1 Protein (1)

    AKR1A1 Antibody (1)

      AKR1A1 cDNA Clone (45)

      BC000670.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_021473.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      BC059133.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      AKR1A1 qPCR Primer (2)

      AKR1A1 の背景知識

      Aldehyde reductase (AKR1A1) is a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins that includes variety of monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase. Aldehyde reductase has wide substrate specificities for carbonyl compounds. These enzymes are implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Aldehyde reductase possess a structure with a beta-alpha-beta fold which contains a novel NADP-binding motif. The binding site is located in a large, deep, elliptical pocket in the C-terminal end of the beta sheet, the substrate being bound in an extended conformation. This binding is more similar to FAD- than to NAD(P)-binding oxidoreductases. AKR1A1 is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue.

      AKR1A1 の参考文献

      • Bohren KM, et al. (1989) The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases. J Biol Chem. 264 (16): 9547-51.
      • Fujii J, et al. (1999) The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome. Cytogenetics and Cell Genetics . 84 (3-4): 33-2.

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