AK2 Proteins, Antibodies, cDNA Clones Research Reagents

All AK2 reagents are produced in house and quality controlled, including 4 AK2 Antibody, 32 AK2 Gene, 1 AK2 IP Kit, 1 AK2 Lysate, 1 AK2 Protein, 1 AK2 qPCR. All AK2 reagents are ready to use.

AK2 Protein (1)

    AK2 Antibody (4)

      AK2 cDNA Clone (32)

      BC009405

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_016895.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001033967.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      AK2 qPCR Primer (1)

      AK2 Lysate (1)

        AK2 の背景知識

        Adenylate kinase 2 (AK2) belongs to the Adenylate kinase family that contains three isozymes: AK1, AK2 and AK3. Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Adenylate kinase2 (AK2) is expressed in mitochondrial intermembrane space. It may play a role in apoptosis. It has been demonstrated that in apoptotic cells AK2 was translocated into the cytosol concomitantly with cytochronme C. Mutations in this gene are the cause of reticular dysgenesis. These mutations result in absent or strongly decreased protein expression. It has been also established that AK2 is specifically expressed in the stria vascularis region of the inner ear, which provides an explanation of the sensorineural deafness in these individuals.

        AK2 の参考文献

        • Lagresle-Peyrou C, et al. (2008) Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nature Genetics. 41: 106-11.
        • Bruns GA, et al. (1977) Adenylate kinase 2, a mitochondrial enzyme. Biochem Genet. 15 (5-6): 477-86.
        • Khler C, et al. (1999) Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis. FEBS Lett. 447 (1): 10-2.

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