AGRP Proteins, cDNA Clones Research Reagents

All AGRP reagents are produced in house and quality controlled, including 39 AGRP Gene, 7 AGRP Lysate, 7 AGRP Protein, 2 AGRP qPCR. All AGRP reagents are ready to use.

AGRP Protein (7)

    AGRP cDNA Clone (39)

    NM_001138.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_007427.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_001091740.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    AGRP Lysate (7)

      AGRP の背景知識

      Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.

      AGRP の参考文献

      • Ilnytska O, et al. (2008) The role of the Agouti-Related Protein in energy balance regulation. Cell Mol Life Sci. 65(17): 2721-31.
      • Pritchard LE, et al. (2005) Agouti-related protein: more than a melanocortin-4 receptor antagonist? Peptides. 26(10): 1759-70.
      • Sttz AM, et al. (2005) The agouti-related protein and its role in energy homeostasis. Peptides. 26(10): 1771-81.
      • Millhauser GL, et al. (2003) Loops and links: structural insights into the remarkable function of the agouti-related protein. Ann N Y Acad Sci. 994: 27-35.

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