AFM Proteins, Antibodies, cDNA Clones Research Reagents

All AFM reagents are produced in house and quality controlled, including 3 AFM Antibody, 26 AFM Gene, 1 AFM Lysate, 1 AFM Protein, 1 AFM qPCR. All AFM reagents are ready to use.

AFM Protein (1)

    AFM Antibody (3)

      AFM cDNA Clone (26)

      NM_001133.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_145146.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      AFM qPCR Primer (1)

      AFM Lysate (1)

        AFM の背景知識

        Afamin is an 87 kDa glycoprotein with five predicted N-glycosylation sites. Afamin's glycan abundance contributes to conformational and chemical inhomogeneity presenting great challenges for molecular structure determination. Afamin, a human plasma glycoprotein and putative transporter of hydrophobic molecules, has been shown to act as extracellular chaperone for poorly soluble, acylated Wnt proteins, forming a stable, soluble complex with functioning Wnt proteins. The 2.1-Å crystal structure of glycosylated human afamin reveals an almost exclusively hydrophobic binding cleft capable of harboring large hydrophobic moieties. Afamin plays a role in anti-apoptotic cellular processes related to oxidative stress and is associated with insulin resistance and other features of metabolic syndrome. Afamin may serve as a new early biomarker for pathological glucose metabolism during pregnancy. And first trimester screening for pre-eclampsia could be provided by a combination of afamin and placental bed vascularization. Moreover, the combination of first trimester serum afamin levels with BMI could provide a possible screening for gestational diabetes mellitus.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.