Adenosine A3 Receptor/ADORA3 cDNA Clones Research Reagents

All Adenosine A3 Receptor/ADORA3 reagents are produced in house and quality controlled, including 15 Adenosine A3 Receptor/ADORA3 Gene, 1 Adenosine A3 Receptor/ADORA3 qPCR. All Adenosine A3 Receptor/ADORA3 reagents are ready to use.

Adenosine A3 Receptor/ADORA3 cDNA Clone (15)


クローニングベクター cDNA 製品

In lentiviral vector


In expression vector

In lentiviral vector

Adenosine A3 Receptor/ADORA3 qPCR Primer (1)

Adenosine A3 Receptor/ADORA3 の背景知識

Adenosine A3 receptor (A3AR) is a Gi-protein-coupled receptor that, when being activated, decreases intracellular cAMP levels. The A3AR gene contains 2 exons that are separated by a single intron of approximately 2.2 kb, located on human chromosome 1p21-p13. There is extensive evidence for the involvement of A3AR in a number of pathophysiological processes including ischemic conditions of the central nervous system and heart and inflammatory states, such as rheumatoid arthritis (RA), Crohn's disease, and tumors. Therefore, A3AR is an important target for a number of inflammatory, neoplastic, and neurodegenerative conditions.

Adenosine A3 Receptor/ADORA3 の参考文献

  • Ren T, Qiu Y, Wu W, et al. Activation of Adenosine A3 Receptor Alleviates TNF-α-Induced Inflammation through Inhibition of the NF-κB Signaling Pathway in Human Colonic Epithelial Cells. Mediators of Inflammation. 2014;2014:818251.
  • Stoddart LA, Kellam B, Briddon SJ, Hill SJ. Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization. British Journal of Pharmacology. 2014;171(16):3827-3844.

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