ACOX1 Proteins, Antibodies, cDNA Clones Research Reagents

All ACOX1 reagents are produced in house and quality controlled, including 6 ACOX1 Antibody, 15 ACOX1 Gene, 1 ACOX1 Lysate, 1 ACOX1 Protein, 1 ACOX1 qPCR. All ACOX1 reagents are ready to use.

ACOX1 Protein (1)

    ACOX1 Antibody (6)

      ACOX1 cDNA Clone (15)

      NM_004035.5

      クローニングベクター cDNA 製品

      In lentiviral vector

      ACOX1 qPCR Primer (1)

      ACOX1 Lysate (1)

        ACOX1 の背景知識

        Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, palmitoyl-CoA oxidase (ACOX1/AOX) and a branched chain acyl-CoA oxidase. The palmitoyl-CoA oxidase (ACOX1/AOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2. Human ACOX1/AOX is a protein of 661-amino acids, including the carboxyl-terminal sequence(Ser-Lys-Leu) known as a minimal peroxisome-targeting signal. Human ACOX1/AOX, the first and rate-limiting enzyme of the peroxisomal β-oxidation pathway, has two isoforms including ACOX1a and ACOX1b, transcribed from a single gene. The human ACOX1b isoform is more effective than the ACOX1a isoform in reversing the Acox1 null phenotype in the mouse partly because of the Substrate utilization differences.

        ACOX1 の参考文献

        • Vluggens A, et al. (2010) Functional significance of the two ACOX1 isoforms and their crosstalks with PPAR alpha and RXR alpha. Laboratory Investigation. 90: 696-708.
        • Chu R, et al. (1995) Overexpression and characterization of the human peroxisomal acyl-CoA oxidase in insect cells. J Biol Chem. 270 (9): 4908-15.
        • Aoyama T, et al. (1994) Molecular cloning and functional expression of a human peroxisomal acyl-coenzyme A oxidase. Biochem Biophys Res Commun. 198 (3): 1113-8.

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