ACBD6 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All ACBD6 reagents are produced in house and quality controlled, including 5 ACBD6 Antibody, 1 ACBD6 ELISA, 17 ACBD6 Gene, 2 ACBD6 IP Kit, 1 ACBD6 Lysate, 1 ACBD6 Protein, 1 ACBD6 qPCR. All ACBD6 reagents are ready to use.

ACBD6 Protein (1)

    ACBD6 Antibody (5)

      ACBD6 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      ACBD6 cDNA Clone (17)

      NM_032360.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_028250.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      ACBD6 qPCR Primer (1)

      ACBD6 Lysate (1)

        ACBD6 の背景知識

        Human acyl-coenzyme A binding domain-containing member 6 (ACBD6) is a modular protein that carries an acyl-CoA binding domain at its N terminus and two ankyrin motifs at its C terminus. In mammals, there are six members of the acyl-CoA binding domain-containing (ACBD) family, and their annotation is not uniform. All six ACBD proteins contain an ACB domain at the N terminus, but they do not share significant homology at the C-terminal region. ACBD6 is a 32 kDa protein that is predicted by sequence analysis to carry an ACB domain between residues 42 and 125 and two ANK motifs at its C terminus. This protein binds long-chain acyl-CoAs with a strong preference for unsaturated, C18:1-CoA and C20:4-CoA, over saturated, C16:0-CoA, acyl species. ACBD6 is not a ubiquitous protein, but it is expressed in hematopoietic tissues and appears to be restricted to primitive stem cells present in those tissues with functions in blood and vessel development. ACBD6 was detected in bone marrow, spleen, placenta, cord blood, circulating CD34+ progenitors, and embryonic-like stem cells derived from placenta. In placenta, the protein was only detected in CD34+ progenitor cells present in blood and CD31+ endothelial cells surrounding the blood vessels. These cells were also positive for the marker CD133, and they probably constitute hemangiogenic stem cells, precursors of both blood and vessels. We propose that human ACBD6 represents a cellular marker for primitive progenitor cells with functions in hematopoiesis and vascular endothelium development.

        ACBD6 の参考文献

        • Soupene E, et al. (2008) Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells. J Lipid Res. 49(5): 1103-12.

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