A33 Proteins, Antibodies, cDNA Clones Research Reagents

GPA33 (Glycoprotein A33, also known as A33), located on 1q24.1, is a Protein Coding gene. The gene produces a 35632 Da protein composed of 319 amino acids. GPA33 is a single-pass type I membrane protein that is expressed in the normal gastrointestinal epithelium and 95% of colon cancers. GPA33 contains oneIg-like C2-type (immunoglobulin-like) domain and oneIg-like V-type (immunoglobulin-like) domain. GPA33 may play a role in cell-cell recognition and signaling. Diseases such as Foodborne Botulism and Wound Botulism are associated with GPA33.

A33 Protein (2)

    A33 Antibody (8)

      A33 cDNA Clone (26)

      NM_005814.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_021610.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      A33 Lysate (2)

        A33 の背景知識

        Cell surface A33 antigen, also known as glycoprotein A33, is a single-pass type I membrane protein that is expressed in the normal gastrointestinal epithelium and 95% of colon cancers. GPA33 contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. Intracellular traffic and recycling to the cell surface appear to play a major role in GPA33 function and to have an influence on its surface density superseding translational regulation. GPA33 has become a promising target of immunologic therapy strategies, but its biologic function and potential role in tumorigenesis are unknown. EpCAM protein and GPA33 mRNA expressions are specific and sensitive markers of Barrett's metaplasia (BM). GPA33 may also play a role in cell-cell recognition and signaling.

        A33 の参考文献

        • Heath J.K., et al., 1997, Proc. Natl. Acad. Sci. USA. 94:469-74.
        • Ritter G., et al., 1997, Biochem. Biophys. Res. Commun. 236:682-6.
        • Frey,D. et al., 2008, Cancer Biother Radiopharm  23 (1):65-73.
        • Rageul,J. et al., 2009, Int J Cancer 125 (12):2802-9. 

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