CoV 3CLpro / 3C-like protease Proteins, cDNA Clones Research Reagents

All CoV 3CLpro / 3C-like protease reagents are produced in house and quality controlled, including 32 CoV 3CLpro / 3C-like protease Gene, 2 CoV 3CLpro / 3C-like protease Lysate, 3 CoV 3CLpro / 3C-like protease Protein. All CoV 3CLpro / 3C-like protease reagents are ready to use.

CoV 3CLpro / 3C-like protease Protein (3)

    CoV 3CLpro / 3C-like protease cDNA Clone (32)

    MERS-CoV

    クローニングベクター cDNA 製品

    In lentiviral vector

    SARS-CoV, isolate WH20

    クローニングベクター cDNA 製品

    In lentiviral vector

    SARS-CoV-2

    In expression vector

    CoV 3CLpro / 3C-like protease Lysate (2)

      CoV 3CLpro / 3C-like protease の背景知識

      3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication and Coronavirus virion production, such as an RNA-dependent RNA polymerase, a helicase, ribonucleases and 3CLpro itself, from two types of polyproteins (pp1a and pp1ab). SARS-CoV 3CLpro exists as a homodimer and each protomer has an active site.

      CoV 3CLpro / 3C-like protease の参考文献

      • Tomonari Muramatsu,et al.Autoprocessing mechanism of severe acute respiratory syndrome coronavirus 3C-like protease (SARS-CoV 3CLpro) from its polyproteins.FEBS Journal.2013
      • Ziebuhr J,Molecular biology of severe acute respiratory syndrome coronavirus. Curr Opin Microbiol.2004
      • Yang H, et al. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci USA.2003

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.