15-PGDH Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

HPGD (15-Hydroxyprostaglandin Dehydrogenase, also known as PGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1), located on 4q34.1, is a Protein Coding gene. The gene produces a 28977 Da protein composed of 266 amino acids. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 and inhibits in vivo proliferation of colon cancer cells. Diseases such as Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1 and Digital Clubbing, Isolated Congenital are associated with HPGD. The related pathways of HPGD include Transcriptional misregulation in cancer and Arachidonic acid metabolism.

15-PGDH Protein (2)

    15-PGDH Antibody (14)

      15-PGDH ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      15-PGDH cDNA Clone (32)

      NM_000860.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008278.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_024390.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      15-PGDH の背景知識

      15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone, and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoarthropathy autosomal recessive (PHOAR), cranio-osteoarthropathy (COA), and isolated congenital nail clubbing.

      15-PGDH の参考文献

      • Patel, FA. et al., 2003, J. Clin. Endocrinol. Metab. 88: 2922-33.
      • McKeown KJ, et al.,2003, J. Clin. Endocrinol. Metab. 88 (4): 1737-41.
      • Yan, M. et al., 2004, Proc. Natl. Acad. Sci. USA. 101: 17468-73.
      • Tariq, M. et al., 2009, J Med Genet. 46 (1): 14-20.

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