Anti-Beta-2 microglobulin Antibody

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Anti-Beta-2 microglobulin Antibody (Rabbit Polyclonal 抗体) の製品情報

製品名
Anti-Beta-2 microglobulin Antibody
検証済のアプリケーション
ELISA
交差反応
Reacts with: Mouse
特異性
Mouse Beta-2 microglobulin
免疫原
Recombinant Mouse B2M / Beta-2-microglobulin protein (Catalog#50957-M08H)
調製
Produced in rabbits immunized with purified, recombinant Mouse B2M / Beta-2-microglobulin (rM B2M / Beta-2-microglobulin; Catalog#50957-M08H; P01887; Met1-Met119). Total IgG was purified by Protein A affinity chromatography.
ソース
Polyclonal Rabbit IgG
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Beta-2 microglobulin Antibody (Rabbit Polyclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Beta-2 microglobulin Antibody: 別名

Anti-beta2-m Antibody; Anti-beta2m Antibody; Anti-Ly-m11 Antibody

Beta-2 microglobulin 背景情報

B2M, also known as β2-Microglobulin or CDABP92, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to theα3 chain. Unlikeα3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M(β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(β2 microglobulin) can indicate non-progression of HIV.
完全な名称
beta-2 microglobulin
参考文献
  • Poulik MD, et al. (1979) Beta 2-Microglobulin: methods and clinical applications. CRC Ctit Rev Clin Lab Sci. 10(3): 225-45.
  • Poulik MD, et al. (1975) Beta2-Microglobulins. Contemp Top Mol Immunol. 4: 157-204.
  • Berggard I. (1976) Beta2-Microglobulins: isolation, properties, and distribution. Fed Proc. 35(5): 1167-70.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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