Mesenchymal Stem Cells

Mesenchymal stem cells, or MSCs, are multipotent adult stem cells that are present in multiple tissues, including umbilical cord, bone marrow and fat tissue. Mesenchymal stem cells can self-renew by dividing and can differentiate into multiple tissues including bone, cartilage, muscle and fat cells, and connective tissue. MSCs are rare in bone marrow, representing ~1 in 10,000 nucleated cells. Although not immortal, they have the ability to expand manyfold in culture while retaining their growth and multilineage potential. MSCs are identified by the expression of many molecules including CD105 (SH2) and CD73 (SH3/4) and are negative for the hematopoietic markers CD34, CD45, and CD14. The properties of MSCs make these cells potentially ideal candidates for tissue engineering. It has been shown that MSCs, when transplanted systemically, are able to migrate to sites of injury in animals, suggesting that MSCs possess migratory capacity. However, the mechanisms underlying the migration of these cells remain unclear. Chemokine receptors and their ligands and adhesion molecules play an important role in tissue-specific homing of leukocytes and have also been implicated in trafficking of hematopoietic precursors into and through tissue. Several studies have reported the functional expression of various chemokine receptors and adhesion molecules on human MSCs. Harnessing the migratory potential of MSCs by modulating their chemokine-chemokine receptor interactions may be a powerful way to increase their ability to correct inherited disorders of mesenchymal tissues or facilitate tissue repair in vivo.

Sino Biological lists the classification tree of Mesenchymal Stem Cells, click to see all the related molecules/targets and research reagents of them.

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal Stem Cell Growth Factors

Mesenchymal Stem Cell Growth Factors

BMPs (Bone Morphogenetic Proteins)

BMPs (Bone Morphogenetic Proteins)

Growth Differentiation Factor (GDF)

Growth Differentiation Factor (GDF)

IGF Ligands

IGF Ligands

Platelet-Derived Growth Factors (PDGFs)

Platelet-Derived Growth Factors (PDGFs)

TGF-beta Family Ligands

TGF-beta Family Ligands

Vascular Endothelial Growth Factors (VEGFs)

Vascular Endothelial Growth Factors (VEGFs)