Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as semaphorins, ephrins and netrin. Plexins function as receptors for the repulsive axonal guidance molecules semaphorins. Intracellular domains of plexins are responsible for initiating cellular signal transduction inducing axon repulsion.
Topographic arrangement of neuronal cell bodies and axonal tracts are crucial for proper wiring of the nervous system. This involves often-coordinated neuronal migration and axon guidance during development. Most neurons migrate from their birthplace to specific topographic coordinates as they adopt the final cell fates and extend axons. The axons follow temporospatial specific guidance cues to reach the appropriate targets. When neuronal or axonal migration or their coordination is disrupted, severe consequences including neurodevelopmental disorders and neurological diseases, can arise. Neuronal and axonal migration shares some molecular mechanisms, as genes originally identified as axon guidance molecules have been increasingly shown to direct both navigation processes. This review focuses on axon guidance pathways that are shown to also direct neuronal migration in the vertebrate spinal cord.
Sino Biological lists the classification tree of Axon Guidance and Neuron Migration, click to see all the related molecules/targets and research reagents of them.
Axon Guidance and Neuron Migration
Axon Guidance and Neuron Migration
BMP Family
BMP Family
Ephrins & Eph Receptors
Ephrins & Eph Receptors
Extracellular Matrix Molecules
Extracellular Matrix Molecules
Netrins and Receptors
Netrins and Receptors
Nogo Proteins and Receptors
Nogo Proteins and Receptors
Repulsive Guidance Molecules and Receptors
Repulsive Guidance Molecules and Receptors
Semaphorins, Plexin Receptors, and Related Molecules
Semaphorins, Plexin Receptors, and Related Molecules
Wnt Family
Wnt Family
Wnt Inhibitors
Wnt Inhibitors
Wnt Intracellular Signaling
Wnt Intracellular Signaling
Wnt Ligands (Wnts)
Wnt Ligands (Wnts)
Wnt Receptors
Wnt Receptors
Wnt Signaling Modulators
Wnt Signaling Modulators
