Innate Immunity

The innate immune system is the phylogenically oldest component of the human immune system. Although it is ancient, the innate immune system is highly complex and consists of barriers to infection (epithelia of skin, gastrointestinal, respiratory, genitourinary tracts), antimicrobial peptides and proteins, humoral components (i.e. complement and opsonins) and cellular components (i.e. neutrophils, monocytes/macrophages, dendritic cells, and innate lymphoid cells). Innate immunity serves as the front line of host defense and plays an essential role in preventing infection while tolerating normal host flora. Defects in innate immunity are associated with invasive, life-threatening infection. Inappropriate activation of the innate immune system can lead to autoinflammatory states. The innate immune system directs the subsequent development of adaptive immune responses. Its proper function is thus critical for health.

Sino Biological lists the classification tree of Innate Immunity, click to see all the related molecules/targets and research reagents of them.

Innate Immunity

Innate Immunity

Mast Cell

Mast Cell

Monocyte/Macrophage

Monocyte/Macrophage