Adaptive Immunity

Adaptive immunity is an important part of the immune system. It is protection from an infectious disease agent that is mediated by B- and T- lymphocytes following exposure to specific antigen, and characterized by immunological memory. Adaptive immunity can result from either previous infection with that agent or vaccination (immunity, active), or transfer of antibody or lymphocytes from an immune donor (immunization, passive).Adaptive immunity is defined by the presence of lymphocytes, either T or B cells, and includes both CD8+ cytotoxic T cells that are the effector cells that directly destroy tumor cells, CD4+ helper T cells that regulate CD8+ T-cell and B-cell function, and B cells that present antigen and produce antibodies. Vertebrates can develop a broad and almost infinite repertoire of antigen-specific receptors, which allows vertebrates to recognize almost any potential pathogen or toxin and to mount antigen-specific responses to it. Two types of adaptive immunity systems have evolved in vertebrates in order to generate immune receptor diversity. The jawed vertebrates strategy uses the V(D)JC recombination to achieve combinatorial diversity of immunoglobulin-based B cell receptors and T cell receptors. The jawless vertebrate strategy uses the somatic rearrangements of variable leucine-rich cassettes in the variable lymphocyte receptors (VLRs). The hallmarks of an adaptive immune system is the production of antigen-specific recognition receptor by somatic gene rearrangement. The long life of some antigen-primed cytotoxic lymphocytes and plasma cells provide protective memory to prevent reinvasion.

Sino Biological lists the classification tree of Adaptive Immunity, click to see all the related molecules/targets and research reagents of them.

Adaptive Immunity

Adaptive Immunity

B cell

B cell

B Cell Activation

B Cell Activation

Other Proteins Involved in Regulating B Cell Activation

Other Proteins Involved in Regulating B Cell Activation

Thymus-Independent B Cell Activation

Thymus-Independent B Cell Activation

B Cell Development and Differentiation

B Cell Development and Differentiation

B Cell Transcription Factors

B Cell Transcription Factors

Cytokines and Chemokines in B Cell Development

Cytokines and Chemokines in B Cell Development

Mediators in B Cell Development

Mediators in B Cell Development

Co-stimulatory & Co-inhibitory Molecules

Co-stimulatory & Co-inhibitory Molecules

Co-stimulatory ILT/CD85 Family Proteins

Co-stimulatory ILT/CD85 Family Proteins

Co-stimulatory TNF Superfamily Molecules

Co-stimulatory TNF Superfamily Molecules

LAIR Family

LAIR Family

Nectin and Nectin-like Ligand/Receptor Co-Signaling Molecules

Nectin and Nectin-like Ligand/Receptor Co-Signaling Molecules

TIM Family Co-Signaling Molecules

TIM Family Co-Signaling Molecules

T Cell

T Cell

Helper T (Th) Cells

Helper T (Th) Cells