Chromatin Remodelers

Chromatin remodelers are multi-protein complexes that use the energy of ATP hydrolysis, in order to slide, exchange or remove nucleosomes. Chromatin remodelers make promoter and enhancer regions either more or less accessible to the transcriptional apparatus, thereby allowing transcription factors to activate or repress, respectively, the transcription of their target genes. Thus, nucleosome occupancy and composition are tailored genome-wide by specialized remodelers.Chromatin remodelers are key players in the regulation of chromatin accessibility and nucleosome positioning on the eukaryotic DNA, thereby essential for all DNA dependent biological processes. Thus, it is not surprising that upon of deregulation of those molecular machines healthy cells can turn into cancerous cells.

Sino Biological lists the classification tree of Chromatin Remodelers, click to see all the related molecules/targets and research reagents of them.