Cell Cycle

The cell cycle is an ordered set of events, culminating in cell growth and division. The cell cycle of eukaryotes can be divided in two brief periods: interphase, during which the cell grows, accumulating nutrients needed for mitosis and duplicating its DNA, and the mitosis (M) phase, during which the cell splits itself into two distinct cells, often called daughter cells. By studying molecular events in cells, interphase is divided into three stages, G1, S, and G2. Thus the cell cycle consists of four phases: G1, S, G2, M.G1 phase is from the end of the previous M phase until the beginning of DNA synthesis, and G stands for gap. During this phase the biosynthetic activities of the cell, which had been considerably slowed down during M phase, resume at a high rate. This phase is marked by synthesis of various enzymes that are required in S phase, mainly those needed for DNA replication.

Early work in frog and invertebrate embryos suggested that cell cycle events are triggered by the activity of a biochemical oscillator centered on cyclin-CDK complexes. The cyclin/CDK complexes induce two processes, duplication of centrosomes and DNA during interphase, and mitosis. The roles of individual cyclins were tested by adding recombinant proteins to cyclin- biologidepleted extracts. Cyclin E supports DNA replication and centrosome duplication, cyclin A supports both of these processes and mitosis, and cyclin B supports mitosis alone.

Sino Biological lists the classification tree of Cell Cycle, click to see all the related molecules/targets and research reagents of them.

Cell Cycle

Cell Cycle

Cell Cycle Checkpoint

Cell Cycle Checkpoint

Checkpoint Kinases

Checkpoint Kinases

Metaphase (Mitotic Spindle) Checkpoints

Metaphase (Mitotic Spindle) Checkpoints

Cell Cycle Regulation

Cell Cycle Regulation

CDC Family

CDC Family

CDKs (Cyclin Dependent Kinases)

CDKs (Cyclin Dependent Kinases)

CKIs(Cyclin Dependent Kinase Inhibitors)

CKIs(Cyclin Dependent Kinase Inhibitors)

Other About Cell Cycle Regulation

Other About Cell Cycle Regulation

p53 & RB

p53 & RB

DNA Repair

DNA Repair

Base Excision Repair

Base Excision Repair

Nucleotide Excision Repair/Transcription Coupled Repair

Nucleotide Excision Repair/Transcription Coupled Repair