Tumor suppressor genes were first identified by making cell hybrids between tumor and normal cells. On some occasions a chromosome from the normal cell reverted the transformed phenotype. Several familial cancers have been shown to be associated with the loss of function of a tumor suppressor gene. They include the retinoblastoma susceptibility gene (RB), Wilms' tumors (WT1), neurofibromatosis type-1 (NF1), familial adenomatosis polyposis coli (FAP), von Hippel-Lindau syndrome (VHL), and those identified through loss of heterozygosity such as in colorectal carcinomas (called DCC for deleted in colon carcinoma) and P53 which was originally thought to be a proto-oncogene. However, the wild-type P53 protein suppresses the activity of mutant alleles of p53 which are the oncogenic forms of P53.
Sino Biological lists the classification tree of Tumor Suppressors, click to see all the related molecules/targets and research reagents of them.