Recombinant Anti-IL4R Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-IL4R Antibody, Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-IL4R Antibody, Rabbit Monoclonal
検証済のアプリケーション
ELISA,FCM
交差反応
Reacts with: Rat
特異性
Rat IL4R
免疫原
Recombinant Rat IL-4R/CD124 Protein (Catalog#80198-R08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Rat IL-4R/CD124 (rR IL-4R/CD124; Catalog#80198-R08H; Q63257-1; Met1-Arg232).
ソース
Monoclonal Rabbit IgG Clone #002
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-IL4R Antibody, Rabbit Monoclonal 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:5000-1:10000
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-IL4R Antibody, Rabbit Monoclonal の画像

Flow cytometric analysis of rat IL4R(CD124) expression on SD rat splenocytes. Cells were stained with purified anti-rat IL4R(CD124), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Recombinant Anti-IL4R Antibody, Rabbit Monoclonal: 別名

Anti-IL4R Antibody; Anti-Il4ra Antibody

IL4R 背景情報

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD124, also known as interleukin 4 receptor (IL4R), is a typeⅠ transmembrane protein that can regulate IgE antibody production in B cells through binding to interleukin 4 and interleukin 13 and promote differentiation of Th2 cells through binding to interleukin 4. The membrane-bound form of CD124 can be hydrolyzed to soluble form which can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells.
完全な名称
interleukin 4 receptor
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参考文献
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.

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