Recombinant Anti-MIG/CXCL9 Antibody, Rabbit Monoclonal

RRID Number: AB_2860492
EliteRmab®, manufactured by recombinant technology

Recombinant Anti-MIG/CXCL9 Antibody, Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-MIG/CXCL9 Antibody, Rabbit Monoclonal
検証済のアプリケーション
ELISA
交差反応
Reacts with: Mouse
特異性
Mouse MIG/CXCL9
Has cross-reactivity in ELISA with
Human CXCL9
No cross-reactivity in ELISA with
Mouse CXCL2
Human CXCL2
免疫原
Recombinant Mouse CXCL9 / MIG protein (Catalog#50155-MNAE)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CXCL9 / MIG (rM CXCL9 / MIG; Catalog#50155-MNAE; P18340; Thr22-Thr126).
ソース
Monoclonal Rabbit IgG Clone #277
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-MIG/CXCL9 Antibody, Rabbit Monoclonal 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-MIG/CXCL9 Antibody, Rabbit Monoclonal: 別名

Anti-BB139920 Antibody; Anti-CMK Antibody; Anti-crg-10 Antibody; Anti-Mig Antibody; Anti-MuMIG Antibody; Anti-Scyb9 Antibody

MIG/CXCL9 背景情報

Chemokine (C-X-C motif) ligand 9 (CXCL9), also known as Monokine induced by gamma interferon (MIG), is a small cytokine belonging to the CXC chemokine family. The function of this chemokine has not been specifically defined; however, it is thought to be involved in T cell trafficking. CXCL9/MIG functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. CXCL9/MIG, together with CXCL10 and CXCL11, may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour endothelial cells secrete high levels of CXCL9 in all, and CXCL10 in most melanoma metastases. Experiment data represent novel mechanisms by which tumour cells in melanoma metastases might use the chemokine-expressing endothelium to leave the tumour and eventually to form additional metastases at distinct sites. Experiment results also improved that CXCL9/MIG plays an important role in CD4+ T lymphocyte recruitment and development of CAV, MOMA-2+ macrophages are the predominant recipient-derived source of CXCL9/MIG, and recipient CD4 lymphocytes are necessary for sustained CXCL9/MIG production and CAV development in this model. Neutralization of the chemokine CXCL9/MIG may have therapeutic potential for the treatment of chronic rejection after heart transplantation.
完全な名称
chemokine (C-X-C motif) ligand 9
参考文献
  • Ruehlmann JM, et al. (2001) MIG (CXCL9) chemokine gene therapy combines with antibody-cytokine fusion protein to suppress growth and dissemination of murine colon carcinoma. Cancer Res. 61(23): 8498-503.
  • Belperio JA, et al. (2003) Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection. J Immunol. 171(9): 4844-52.
  • Colvin RA, et al. (2004) Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function. J Biol Chem. 279(29): 30219-27.
  • Valbuena G, et al. (2003) Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. Am J Pathol. 163(4): 1357-69.
  • CXCL9 regulates acetaminophen‑induced liver injury via CXCR3
    Author
    Song, X;Shen, Y;Lao, Y;Tao, Z;Zeng, J;
    Year
    2019
    Journal
    Experimental and Therapeutic Medicine
    Application
    animal-based
  • CXCL9 regulates acetaminophen-induced liver injury via CXCR3
    Author
    Song, X;Shen, Y;Lao, Y;Tao, Z;Zeng, J;Wang, J;Wu, H;
    Year
    2019
    Journal
    Exp Ther Med
    Application
    animal-based

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Mouse MAb

Rabbit PAb

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