Recombinant Anti-IL-18 Antibody, Rabbit Monoclonal

RRID Number: AB_2860477
EliteRmab®, manufactured by recombinant technology

Recombinant Anti-IL-18 Antibody, Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-IL-18 Antibody, Rabbit Monoclonal
検証済のアプリケーション
ELISA(Cap)
交差反応
Reacts with: Mouse
特異性
Mouse IL-18
免疫原
Recombinant Mouse IL18 / IL-18 / Interleukin 18 Protein (Catalog#50073-MNAE)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL18 / IL-18 / Interleukin 18 (rM IL18 / IL-18 / Interleukin 18; Catalog#50073-MNAE; P70380; Asn36-Ser192).
ソース
Monoclonal Rabbit IgG Clone #169
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-IL-18 Antibody, Rabbit Monoclonal 検証済のアプリケーション

Notes
ELISA(Cap): This antibody will detect Mouse IL18 / IL-18 / Interleukin 18 in ELISA pair set (Catalog: # SEK50073). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 50073-R167).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-IL-18 Antibody, Rabbit Monoclonal: 別名

Anti-Igif Antibody; Anti-Il-18 Antibody

IL-18 背景情報

Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1-like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cell -, IL-4- and STAT6-dependent fashion. IL-18 and T cell receptor-mediated stimulation could induce naive CD4+ T cells to develop into IL-4-producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in the regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feedback to promote Th1 cell development in the synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.
完全な名称
interleukin 18
研究分野
Related Pathways
  • IL1 signaling pathway
    IL1 signaling pathway
参考文献
  • Dinarello CA. (1999) IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol. 103: 11-24.
  • Takeda K, et al.. (1998) Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity. 8(3): 383-90.
  • Gracie JA, et al.. (1999) A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest. 104(10): 1393-401.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

カートに追加しました カートに追加しませんでした カートを更新しています。少々お待ちください U.S.A.