Recombinant Anti-EpCAM Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology

Recombinant Anti-EpCAM Antibody, Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-EpCAM Antibody, Rabbit Monoclonal
検証済のアプリケーション
ELISA(Cap)
交差反応
Reacts with: Mouse
特異性
Mouse EpCAM
免疫原
Recombinant Mouse EpCAM / TROP-1 / TACSTD1 Protein (Catalog#50591-M08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse EpCAM / TROP-1 / TACSTD1 (rM EpCAM / TROP-1 / TACSTD1; Catalog#50591-M08H; NP_032558.2; Met1-Thr266).
ソース
Monoclonal Rabbit IgG Clone #052
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-EpCAM Antibody, Rabbit Monoclonal 検証済のアプリケーション

Notes
ELISA(Cap): This antibody will detect Mouse EpCAM / TROP-1 / TACSTD1 in ELISA pair set (Catalog: # SEK50591). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 50591-R002).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-EpCAM Antibody, Rabbit Monoclonal: 別名

Anti-CD326 Antibody; Anti-EGP Antibody; Anti-EGP-2 Antibody; Anti-Egp314 Antibody; Anti-Ep-CAM Antibody; Anti-EpCAM1 Antibody; Anti-GA733-2 Antibody; Anti-gp40 Antibody; Anti-Ly74 Antibody; Anti-Tacsd1 Antibody; Anti-Tacstd1 Antibody; Anti-TROP1 Antibody

EpCAM 背景情報

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â…transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.
完全な名称
epithelial cell adhesion molecule
参考文献
  • Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
  • Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
  • Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
  • Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.

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Mouse MAb

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Mouse MAb

Rabbit PAb

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