Recombinant Anti-CTLA-4 Antibody, Rabbit Monoclonal

RRID Number: AB_2860510
EliteRmab®, manufactured by recombinant technology

Recombinant Anti-CTLA-4 Antibody, Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-CTLA-4 Antibody, Rabbit Monoclonal
検証済のアプリケーション
ELISA
交差反応
Reacts with: Mouse
特異性
Mouse CTLA-4
No cross-reactivity in ELISA with
Human CTLA4
Mouse CD28
Mouse ICOS
Cynomolgus CTLA4
免疫原
Recombinant Mouse CTLA-4 / CD152 protein (Catalog#50503-M08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CTLA-4 / CD152 (rM CTLA-4 / CD152; Catalog#50503-M08H; NP_033973.2; Met1-Phe162).
ソース
Monoclonal Rabbit IgG Clone #037
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-CTLA-4 Antibody, Rabbit Monoclonal 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-CTLA-4 Antibody, Rabbit Monoclonal: 別名

Anti-Cd152 Antibody; Anti-Ctla-4 Antibody; Anti-Ly-56 Antibody

CTLA-4 背景情報

Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).
完全な名称
cytotoxic T-lymphocyte-associated protein 4
参考文献
  • Slavik JM, et al. (1999) CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res. 19(1): 1-24.
  • Holmberg D, et al. (2005) CTLA-4 (CD152) and its involvement in autoimmune disease. Autoimmunity. 38(3): 225-33.
  • Chin LT, et al. (2008) Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases. Chang Gung Med J. 31(1): 1-15.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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