Recombinant Anti-CD98 Antibody, Rabbit Monoclonal

RRID Number: AB_2860523
EliteRmab®, manufactured by recombinant technology

Recombinant Anti-CD98 Antibody, Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-CD98 Antibody, Rabbit Monoclonal
検証済のアプリケーション
IHC-P
交差反応
Reacts with: Mouse
特異性
Mouse CD98
No cross-reactivity in ELISA with
Human SLC3A2
免疫原
Recombinant Mouse SLC3A2 protein (Catalog#50813-M07H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SLC3A2 (rM SLC3A2; Catalog#50813-M07H; NP_001154885.1; Ala139-Ala565).
ソース
Monoclonal Rabbit IgG Clone #048
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-CD98 Antibody, Rabbit Monoclonal 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-CD98 Antibody, Rabbit Monoclonal の画像

Immunochemical staining of mouse SLC3A2 in mouse kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to nephric tubule.

Recombinant Anti-CD98 Antibody, Rabbit Monoclonal: 別名

Anti-4F2 Antibody; Anti-4F2HC Antibody; Anti-AI314110 Antibody; Anti-Cd98 Antibody; Anti-Ly-10 Antibody; Anti-Ly-m10 Antibody; Anti-Ly10 Antibody; Anti-Mdu1 Antibody; Anti-Mgp-2hc Antibody; Anti-NACAE Antibody

CD98 背景情報

4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A transporter family. SLC3A2 / MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester stage. SLC3A2 / MDU1 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. It is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. SLC3A2 / MDU1 is also expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco2-BBE. SLC3A2 / MDU1 is required for the function of light chain amino-acid transporters. It is involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. SLC3A2 / MDU1 is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, SLC3A2 / MDU1 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC3A2 / MDU1 plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It is required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, SLC3A2 / MDU1 is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.
完全な名称
solute carrier family 3 (amino acid transporter heavy chain), member 2
参考文献
  • Torrents D. et al., 1998, J Biol Chem. 273: 32437-45.
  • Pfeiffer R. et al., 1999, EMBO J. 18: 49-57.
  • Broeer A. et al., 2000, Biochem J. 349: 787-95.
  • Yanagida O. et al., 2001, Biochim Biophys Acta. 1514: 291-302.
  • Broeer A. et al., 2001, Biochem J. 355: 725-31.
  • Fort J. et al., 2007, J Biol Chem. 282: 31444-52.
  • Mayya V. et al., 2009, Sci Signal. 2: RA46-RA46.

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