Recombinant Anti-CD64 Antibody (FITC), Rabbit Monoclonal

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Recombinant Anti-CD64 Antibody (FITC), Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-CD64 Antibody (FITC), Rabbit Monoclonal
検証済のアプリケーション
FCM
交差反応
Reacts with: Mouse
特異性
Mouse CD64
免疫原
Recombinant Mouse CD64 / FCGR1 protein (Catalog#50086-M08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD64 / FCGR1 (rM CD64 / FCGR1; Catalog#50086-M08H; NP_034316.1; Met 1-Pro 297) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
ソース
Monoclonal Rabbit IgG Clone #027
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
標識物
FITC
濃度
10 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Recombinant Anti-CD64 Antibody (FITC), Rabbit Monoclonal の画像

Flow cytometric analysis of Mouse FCGR1(CD64) expression on Raw264.7 cells. Cells were stained with FITC-conjugated anti-Mouse FCGR1(CD64). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Recombinant Anti-CD64 Antibody (FITC), Rabbit Monoclonal: 別名

Anti-AI323638 Antibody; Anti-AV092959 Antibody; Anti-CD64 Antibody; Anti-FcgammaRI Antibody; Anti-IGGHAFC Antibody

CD64 背景情報

High affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membraneglycoprotein and a member of the immunoglobulin superfamily. CD64 is a high affinity receptor for the Fc region of IgG gamma and functions in both innate and adaptive immune responses. Receptors that recognize the Fc portion of IgG function in the regulation of immune response and are divided into three classes designated CD64, CD32, and CD16. CD64 is structurally composed of asignal peptidethat allows its transport to the surface of a cell, threeextracellularimmunoglobulin domainsof the C2-type that it uses to bind antibody, a hydrophobictransmembrane domain, and a short cytoplasmic tail. CD64 isconstitutivelyfound on only macrophages and monocytes, but treatment of polymorphonuclear leukocyteswith cytokines likeIFNγandG-CSFcan induce CD64 expression on these cells. The inactivation of the mouse CD64 resulted in a wide range of defects in antibody Fc-dependent functions. Mouse CD64 is an early participant in Fc-dependent cell activation and in the development of immune responses.
完全な名称
Fc receptor, IgG, high affinity I
研究分野
参考文献
  • Allen J.M., et al.,(1988), Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI). Nucleic Acids Res. 16:11824-11824.
  • Allen J.M., et al., (1989), Isolation and expression of functional high-affinity Fc receptor complementary DNAs.Science 243:378-381.
  • Porges A.J., et al.,(1992), Novel Fc gamma receptor I family gene products in human mononuclear cells.J. Clin. Invest. 90:2102-2109.

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