Recombinant Anti-Carbonic Anhydrase IX Antibody, Rabbit Monoclonal

RRID Number: AB_2860515
EliteRmab®, manufactured by recombinant technology

Recombinant Anti-Carbonic Anhydrase IX Antibody, Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-Carbonic Anhydrase IX Antibody, Rabbit Monoclonal
検証済のアプリケーション
IHC-P
交差反応
Reacts with: Mouse
特異性
Mouse Carbonic Anhydrase IX
免疫原
Recombinant Mouse Carbonic Anhydrase IX / CAR9 protein (Catalog#50660-M08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Carbonic Anhydrase IX / CAR9 (rM Carbonic Anhydrase IX / CAR9; Catalog#50660-M08H; NP_647466.2; Met1-Asp390).
ソース
Monoclonal Rabbit IgG Clone #001
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-Carbonic Anhydrase IX Antibody, Rabbit Monoclonal 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
IHC-P 1:250-1:1000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-Carbonic Anhydrase IX Antibody, Rabbit Monoclonal の画像

Immunochemical staining of mouse CAR9 in mouse stomach (from 2 donors) with rabbit monoclonal antibody (1:500, formalin-fixed paraffin embedded sections).

Carbonic Anhydrase IX 背景情報

Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.
完全な名称
carbonic anhydrase IX
研究分野
参考文献
  • Loncaster JA, et al. (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 61(17): 6394-9.
  • Zvada J, et al. (2003) Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Br J Cancer. 89(6): 1067-71.
  • Pan P, et al. (2006) Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. J Physiol. 571(Pt 2): 319-27.
  • Zhou GX, et al. (2010) Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials. Urology. 75(2): 257-61.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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