Recombinant Anti-Von Willebrand Factor/vWF Antibody, Rabbit Monoclonal

RRID Number: AB_2860257
EliteRmab®, manufactured by recombinant technology

Recombinant Anti-Von Willebrand Factor/vWF Antibody, Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-Von Willebrand Factor/vWF Antibody, Rabbit Monoclonal
検証済のアプリケーション
ELISA,ELISA(Det),IHC-P
交差反応
Reacts with: Human
特異性
Human Von Willebrand Factor/vWF
免疫原
Recombinant Human vWF protein (Catalog#10973-H08C)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human von Willebrand factor (rh vWF; Catalog#10973-H08C; AAB59458.1; Met1-Lys2813).
ソース
Monoclonal Rabbit IgG Clone #111
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-Von Willebrand Factor/vWF Antibody, Rabbit Monoclonal 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:5000-1:10000
IHC-P 1:500-1:2000
ELISA(Det) 1:1000-1:10000
Notes
ELISA(Det): This antibody will detect Human VWF / Von Willebrand Factor in ELISA pair set (Catalog: # SEKA10973). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 10973-MM05).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-Von Willebrand Factor/vWF Antibody, Rabbit Monoclonal の画像

Immunohistochemical staining of formalin fixed, paraffin-embedded human tonsil showing blood vessel staining (1:1000).
Immunohistochemical staining of formalin fixed, paraffin-embedded human stomach showing blood vessel staining (1:1000).
Immunohistochemical staining of formalin fixed, paraffin-embedded human muscle showing blood vessel staining (1:1000).
Immunohistochemical staining of formalin fixed, paraffin-embedded human lymphonode showing blood vessel staining (1:1000).

Recombinant Anti-Von Willebrand Factor/vWF Antibody, Rabbit Monoclonal: 別名

Anti-F8VWF Antibody; Anti-Von Willebrand Factor Antibody; Anti-VWD Antibody

Von Willebrand Factor/vWF 背景情報

Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. From studies it appears that VWF protein uncoils under these circumstances, decelerating passing platelets. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thrombocytopenic purpura, Stroke, Heyde's syndrome, possibly hemolytic-uremic syndrome and so on.
完全な名称
von Willebrand factor
参考文献
  • Sadler JE. (1998) Biochemistry and genetics of von Willebrand factor. Annu Rev Biochem, 67: 395-424.
  • Batlle J, et al. (2009) Von Willebrand factor/factor VIII concentrates in the treatment of von Willebrand disease. Blood Coagul Fibrinolysis. 20(2):89-100.
  • Sadler JE. (2009) von Willebrand factor assembly and secretion. J Thromb Haemost. 7 Suppl 1:24-7.
  • Auton M, et al. (2010) The mechanism of VWF-mediated platelet GPIbalpha binding. Biophys J. 99(4):1192-201.
  • Bowen DJ. (2010) Sugar targets VWF for the chop. Blood. 115(13):2565.
  • Lpez JA, et al. (2010) VWF self-association: more bands for the buck. Blood. 116(19):3693-4.

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