Recombinant Anti-TIM-3 Antibody, Rabbit Monoclonal

RRID Number: AB_2860165
EliteRmab®, manufactured by recombinant technology

Recombinant Anti-TIM-3 Antibody, Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-TIM-3 Antibody, Rabbit Monoclonal
検証済のアプリケーション
ELISA,ELISA(Cap)
交差反応
Reacts with: Human
特異性
Human TIM-3
免疫原
Recombinant Human TIMD3 protein (Catalog#10390-H08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human TIMD3 (rh TIMD3; Catalog#10390-H08H; NP_116171.3; Met 1-Arg 200).
ソース
Monoclonal Rabbit IgG Clone #024
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-TIM-3 Antibody, Rabbit Monoclonal 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:5000-1:10000
ELISA(Cap) 1:250-1:2000
Notes
ELISA(Cap): This antibody will detect Human TIM-3 / HAVCR2 in ELISA pair set (Catalog: # SEK10390). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 10390-MM04).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-TIM-3 Antibody, Rabbit Monoclonal: 別名

Anti-CD366 Antibody; Anti-HAVcr-2 Antibody; Anti-HAVCR2 Antibody; Anti-KIM-3 Antibody; Anti-Tim-3 Antibody; Anti-TIM3 Antibody; Anti-TIMD-3 Antibody; Anti-TIMD3 Antibody

TIM-3 背景情報

Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both the mouse and human. Recently, the identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In the tumor rejection model, the soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in the tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response.
完全な名称
hepatitis A virus cellular receptor 2
研究分野
参考文献
  • Geng H, et al. (2006) Soluble form of T cell Ig mucin 3 is an inhibitory molecule in T cell-mediated immune response. J Immunol. 176(3): 1411-20.
  • Anderson AC, et al. (2006) TIM-3 in autoimmunity. Curr Opin Immunol. 18(6): 665-9.
  • Anderson DE. (2007) TIM-3 as a therapeutic target in human inflammatory diseases. Expert Opin Ther Targets. 11(8): 1005-9.
  • Pan HF, et al. (2010) TIM-3 as a new therapeutic target in systemic lupus erythematosus. Mol Biol Rep. 37(1): 395-8.
  • Soluble Tim3 detection by time-resolved fluorescence immunoassay and its application in membranous nephropathy
    Author
    Chen, M;Wang, L;Wang, Y;Zhou, X;Liu, X;Chen, H;Huang, B;Hu, Z;
    Year
    2020
    Journal
    J. Clin. Lab. Anal.
    Application
    ELISA (assay comparasion)

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