A synthetic peptide corresponding to the N-terminus of the human Sox2.
This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the N-terminus of the human Sox2.
Monoclonal Rabbit IgG Clone #017
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
SOX2, also known as ANOP3, is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP26. SOX2 is critical for early embryogenesis and for embryonic stem cell pluripotency. It keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Defects in SOX2 can cause microphthalmia, syndromic, 3. A disease characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
SRY (sex determining region Y)-box 2
Lu Y, et al., 2010, PLoS ONE. 5(6): e11022.
Gontan C, et al., 2008, Dev. Biol. 317 (1): 296-309.
Shi W, et al., 2006, J. Biol. Chem. 281 (33): 23319-25.