Anti-S100A9 Antibody (FITC), Mouse Monoclonal

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Anti-S100A9 Antibody (FITC), Mouse Monoclonal の製品情報

製品名
Anti-S100A9 Antibody (FITC), Mouse Monoclonal
検証済のアプリケーション
FCM
交差反応
Reacts with: Human
特異性
Human S100A9
免疫原
Recombinant Human S100A9 protein (Catalog#11145-H08B)
調製
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human S100A9 (rh S100A9; Catalog#11145-H08B; NP_002956.1; Met1-Pro114) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
ソース
Monoclonal Mouse IgG2b Clone #01
精製
Protein A
緩衝液
PBS solution containing 0.5% BSA and 0.09% sodium azide
標識物
FITC
濃度
10 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-S100A9 Antibody (FITC), Mouse Monoclonal の画像

Profile of anti-S100A9 reactivity on MCF-7 cells analyzed by flow cytometry. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and stained with FITC conjugated Mouse anti-Human S100A9, The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-S100A9 Antibody (FITC), Mouse Monoclonal: 別名

Anti-60B8AG Antibody; Anti-CAGB Antibody; Anti-CFAG Antibody; Anti-CGLB Antibody; Anti-L1AG Antibody; Anti-LIAG Antibody; Anti-MAC387 Antibody; Anti-MIF Antibody; Anti-MRP-14 Antibody; Anti-MRP14 Antibody; Anti-NIF Antibody; Anti-P14 Antibody

S100A9 背景情報

S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A9, also known as S100 calciumbinding protein A9, S100A9, and CAGB, is a member of the S-100 family. S100A9 is expressed by macrophages in acutely inflammed tissues and in chronic inflammation. It is also expressed in epithelial cells constitutively or induced during dermatoses. S100A9 is a calcium-binding protein. It has anti-microbial activity towards bacteria and fungi. The anti-microbial and proapoptotic activity of S100A9 is inhibited by zinc ions. S100A9 plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS). It promotes tubulin polymerization when unphosphorylated. It also promotes phagocyte migration and infiltration of granulocytes at sites of wounding. S100A9 plays a role as a proinflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1.
完全な名称
S100 calcium binding protein A9
参考文献
  • Miyasaki KT. et al., 1993, J Dent Res. 72: 517-23.
  • Fanò G. et al., 1995, Prog Neurobiol. 46 (1): 71-82.
  • Vogl T. et al., 2004, Blood. 104: 4260-8.
  • Viemann D. et al., 2005, Blood. 105: 2955-62.
  • Nakatani Y. et al., 2005, Mediators Inflamm. 2005: 280-92.
  • Bjoerk P. et al., 2009, PLoS Biol. 7: E97-E97.

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