Recombinant Anti-PCSK9 Antibody, Rabbit Monoclonal

RRID Number: AB_1960425
EliteRmab®, manufactured by recombinant technology

Recombinant Anti-PCSK9 Antibody, Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-PCSK9 Antibody, Rabbit Monoclonal
検証済のアプリケーション
ELISA
交差反応
Reacts with: Human
特異性
Human PCSK9
免疫原
Recombinant Human PCSK9 protein (Catalog#10594-H08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human PCSK9 (rhPCSK9; Catalog#10594-H08H; aa 1-692; AAV67948.1).
ソース
Monoclonal Rabbit IgG Clone #A1
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-PCSK9 Antibody, Rabbit Monoclonal 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-PCSK9 Antibody, Rabbit Monoclonal: 別名

Anti-FH3 Antibody; Anti-HCHOLA3 Antibody; Anti-LDLCQ1 Antibody; Anti-NARC-1 Antibody; Anti-NARC1 Antibody; Anti-PC9 Antibody

PCSK9 背景情報

Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
完全な名称
proprotein convertase subtilisin/kexin type 9
参考文献
  • Sseidah, N.G. et al., 2003, Proc. Natl. Acad. Sci. USA. 100: 928-933.
  • Beyer, T.P. et al., 2007, J. Lipid. Res. 48: 1488-1498
  • Shan, L. et al., 2008, Biochem. Biophys. Res. Commun. 375: 69-73.
  • Benjannet, S. et al., 2005, J. Biol. Chem. 279: 48865-48875.
  • Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.

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