Recombinant Anti-NKp30/NCR3 Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology

Recombinant Anti-NKp30/NCR3 Antibody, Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-NKp30/NCR3 Antibody, Rabbit Monoclonal
検証済のアプリケーション
WB,ELISA
交差反応
Reacts with: Human
特異性
Human NKp30/NCR3
免疫原
Recombinant Human NCR3 / CD337 Protein (Catalog#10480-H08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human NCR3 / CD337 (rh NCR3 / CD337; Catalog#10480-H08H; NP_667341.1; Met1-Gly135).
ソース
Monoclonal Rabbit IgG Clone #012
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-NKp30/NCR3 Antibody, Rabbit Monoclonal 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
WB 1:500-1:1000
ELISA 1:25000-1:50000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-NKp30/NCR3 Antibody, Rabbit Monoclonal の画像

Anti-NCR3 rabbit monoclonal antibody at 1:500 dilution

Lane A: K562 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:22 kDa

Observed band size:14 kDa

Recombinant Anti-NKp30/NCR3 Antibody, Rabbit Monoclonal: 別名

Anti-1C7 Antibody; Anti-CD337 Antibody; Anti-DAAP-90L16.3 Antibody; Anti-LY117 Antibody; Anti-MALS Antibody; Anti-NCR3 Antibody; Anti-NKp30 Antibody

NKp30/NCR3 背景情報

Natural Cytotoxicity Triggering Receptor 3, NCR3, also known as NKp30, or CD337, is a natural cytotoxicity receptor, expressed on subsets of human peripheral blood NK cells, involved in NK cell killing of tumor cells and immature dendritic cells. The cellular ligand for NKp30 has remained elusive, but the membrane-associated heparan sulfate (HS) proteoglycans are involved in the recognition of cellular targets by NKp30 was recently reported. NKp30 is a member of the immunoglobulin superfamily and one of three existing natural cytotoxicity-triggering receptors. NKp30 is a glycosylated protein and is thought to be selectively expressed in resting and activated natural killer cells. NKp30 is a stimulatory receptor on human NK cells implicated in tumor immunity and is capable of promoting or terminating dendritic cell maturation. NCR3 may play a role in inflammatory and infectious diseases.
完全な名称
natural cytotoxicity triggering receptor 3
参考文献
  • Warren HS, et al. (2005) Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan. J Immunol. 175(1): 207-12.
  • Mulcahy H, et al. (2006) LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection. Immunogenetics. 57(12): 893-903.
  • Hsieh CL, et al. (2006) NKp30 is a functional activation receptor on a subset of rat natural killer cells. Eur J Immunol. 36(8): 2170-80.
  • Ponnampalam AP, et al. (2008) Identification and hormonal regulation of a novel form of NKp30 in human endometrial epithelium. Eur J Immunol. 38(1): 216-26.

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