Recombinant Anti-Her2/ERBB2 Antibody, Rabbit Monoclonal

RRID Number: AB_2860046
EliteRmab®, manufactured by recombinant technology

Recombinant Anti-Her2/ERBB2 Antibody, Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-Her2/ERBB2 Antibody, Rabbit Monoclonal
検証済のアプリケーション
ELISA(Det)
交差反応
Reacts with: Human
特異性
Human Her2/ERBB2
免疫原
Recombinant Human HER2 / ERBB2 Protein (Catalog#10004-H08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human HER2 / ERBB2 (rh HER2 / ERBB2; Catalog#10004-H08H; NP_004439.2; Met1-Thr652).
ソース
Monoclonal Rabbit IgG Clone #205
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-Her2/ERBB2 Antibody, Rabbit Monoclonal 検証済のアプリケーション

Notes
ELISA(Det): This antibody will detect Human HER2 / ERBB2 in ELISA pair set (Catalog: # SEKA10004). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 10004-R511).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-Her2/ERBB2 Antibody, Rabbit Monoclonal: 別名

Anti-CD340 Antibody; Anti-ENV Antibody; Anti-ENVW Antibody; Anti-ERVWE1 Antibody; Anti-HER-2 Antibody; Anti-HER-2/neu Antibody; Anti-HER2 Antibody; Anti-HERV-7q Antibody; Anti-HERV-W-ENV Antibody; Anti-HERV7Q Antibody; Anti-HERVW Antibody; Anti-HERVWENV Antibody; Anti-MLN 19 Antibody; Anti-MLN19 Antibody; Anti-NEU Antibody; Anti-NGL Antibody; Anti-TKR1 Antibody

Her2/ERBB2 背景情報

Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
完全な名称
erb-b2 receptor tyrosine kinase 2
参考文献
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
  • Exosomes containing miRNAs targeting HER2 synthesis and engineered to adhere to HER2 on tumor cells surface exhibit enhanced antitumor activity
    Author
    Wang, L;Zhou, X;Zou, W;Wu, Y;Zhao, J;Chen, X;Zhou, GG;
    Year
    2020
    Journal
    assets.researchsquare.com

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