Recombinant Anti-CD8 alpha Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology

Recombinant Anti-CD8 alpha Antibody, Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-CD8 alpha Antibody, Rabbit Monoclonal
検証済のアプリケーション
IHC-P
交差反応
Reacts with: Human, Ferret
特異性
Human CD8 alpha
免疫原
Recombinant Human CD8a / Lyt2 protein (Catalog#10980-H08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD8a / Lyt2 (rh CD8a / Lyt2; Catalog#10980-H08H; NP_001759.3; Met1-Asp182).
ソース
Monoclonal Rabbit IgG Clone #081
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-CD8 alpha Antibody, Rabbit Monoclonal 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-CD8 alpha Antibody, Rabbit Monoclonal の画像

Immunochemical staining CD8a in human lymph node with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunochemical staining CD8A in Ferret spleen with rabbit monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.

Recombinant Anti-CD8 alpha Antibody, Rabbit Monoclonal: 別名

Anti-CD8 Antibody; Anti-CD8 alpha Antibody; Anti-Leu-2 Antibody; Anti-Leu2 Antibody; Anti-MAL Antibody; Anti-p32 Antibody; Anti-p32 186910 Antibody

CD8 alpha 背景情報

T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
完全な名称
CD8a molecule
参考文献
    References Devine, L. et al., 2000, J Immunol. 164 (2): 833-8. Arcaro, A. et al., 2000, J Immunol. 165 (4): 2068-76. Saha, K. et al., 2001, Nat Med. 7 (1): 65-72. Romero, P. et al., 2005, Eur J Immunol. 35 (11): 3092-4.

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