Recombinant Anti-CEACAM6 Antibody (PerCP), Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-CEACAM6 Antibody (PerCP), Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-CEACAM6 Antibody (PerCP), Rabbit Monoclonal
検証済のアプリケーション
FCM
交差反応
Reacts with: Human
特異性
Human CEACAM6
免疫原
Human cell-derived rhCEACAM6 (Catalog#10823-H08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human CEACAM6 / CD66c (rh CEACAM6 / CD66c; 10823-H08H; Met 1-Gly 320; NP_002474.4) and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed.
ソース
Monoclonal Rabbit IgG Clone #408
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
標識物
PerCP
濃度
10 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Recombinant Anti-CEACAM6 Antibody (PerCP), Rabbit Monoclonal の画像

Flow cytometric analysis of human CEACAM6 expression on human whole blood granulocytes. Human whole blood granulocytes were stained with PerCP-conjugated anti-Human CEACAM6. The histogram were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes.

Recombinant Anti-CEACAM6 Antibody (PerCP), Rabbit Monoclonal: 別名

Anti-CD66c Antibody; Anti-CEA Antibody; Anti-CEAL Antibody; Anti-NCA Antibody

CEACAM6 背景情報

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It s a glycosylphosphatidylinositol-linked immunoglobulin superfamily member that is overexpressed in a variety of human cancers, including colon, breast and lung and is associated with tumourigenesis, tumour cell adhesion, invasion and metastasis. CEACAM6 is a unique mediator of migration and invasion of drug resistant oestrogen-deprived breast cancer cells, and this protein could be an important biomarker of metastasis. CEACAM6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.
完全な名称
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
参考文献
  • Duxbury MS, et al. (2004) Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness. Oncogene. 23(34): 5834-42.
  • Lewis-Wambi JS, et al. (2008) Overexpression of CEACAM6 promotes migration and invasion of oestrogen-deprived breast cancer cells. Eur J Cancer. 44(12): 1770-9.

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